African Journal of Respiratory Medicine
The treatment and management of asthma using sirtuins

Opinion - (2023) Volume 18, Issue 2

Jericho Eden*
*Correspondence: Jericho Eden, Department of Medicine, University of Zulia, Venezuela, Email:

Received: 01-Mar-2023, Manuscript No. ajrm-23-98195; Editor assigned: 03-Mar-2023, Pre QC No. ajrm-23-98195 (PQ); Reviewed: 17-Mar-2023, QC No. ajrm-23-98195; Revised: 22-Mar-2023, Manuscript No. ajrm-23-98195 (R); Published: 29-Mar-2023, DOI: 10.54931/1747-5597.23.18.78

Department of Medicine, University of Zulia, Venezuela


Sirtuins are nicotinamide adenine dinucleotide (NAD+) subordinate lysine deacylases and deacetylases that take part in different cell processes, including transcriptional movement, energy digestion, DNA harm reaction, irritation, apoptosis, autophagy, and oxidative pressure. Accordingly, sirtuins are connected to various pathophysiological processes, like cardiovascular illnesses, metabolic sicknesses, immune system illnesses, irresistible infections, and respiratory infections.


Asthma is the most well-known respiratory sickness, which is described via aviation route aggravation and aviation route rebuilding. Collecting proof has shown that sirtuins are engaged with the pathogenesis of asthma. Besides, a few investigations have recommended that sirtuin modulators are likely specialists for the treatment of asthma by means of modification of the articulation or action of sirtuins. In this survey, we outline the job of sirtuins in asthma, talk about related atomic systems, and assess the sirtuins-designated treatment for asthma.

Asthma is perhaps of the most widely recognized respiratory illness, described by factor respiratory side-effects and wind current constraint. As per a public overview, 7.7% of individuals in the US have asthma. The pervasiveness of asthma among grown-ups in China is 4.2%, with an expected 45.7 million asthma patients. Past breathed in corticosteroids and long-acting β2 agonists, other extra treatments are likewise thought of, for example, leukotriene receptor bad guys, long-acting muscarinic adversaries, fundamental corticosteroids, and biologics. Regardless of such countless choices for treating asthma, many individuals with asthma remain inadequately controlled. Asthma causes a weighty sickness weight to society. Expanding quantities of individuals are participated in research on asthma to explain the pathogenesis of asthma and better treat it. Be that as it may, many inquiries encompassing asthma require further review.

The sirtuin (SIRT) family comprises of seven individuals (SIRT1-SIRT7), what share homology with the yeast quiet data controller 2 (Sir2) protein. SIRTs certainly stand out throughout recent many years. Unique examinations have demonstrated that SIRTs, as class III lysine deacetylases (KDACs), are broadly engaged with directing maturing and life expectancy in people. Ensuing examinations have shown that SIRTs are engaged with different cell capabilities and physiological cycles through their deacetylase and mono-adenosine diphosphate (ADP) ribosyltransferase exercises, for example, transcriptional action, energy digestion, DNA harm reaction, irritation, apoptosis, autophagy, and oxidative pressure. Numerous discoveries on SIRTs have laid out their capability in the pathogenesis of asthma. Here, to give an original remedial system to treatment, we checked on the writing to examine the jobs and related sub-atomic pathways of every individual from the SIRT family in asthma.


Despite headways, research progress and clinical use of SIRT modulators have not gone without a hitch. The low selectivity of SIRT modulators has become one of the primary snags restricting exploration progress. As the first found SIRT1 activator, resveratrol can assume a specific part in other SIRTs other than following up on SIRT1. Activators might have better selectivity and less unfavorable impacts than inhibitors. In any case, activators, particularly unambiguous and specific activators, are uncommon in number comparative with inhibitors. Hence, further investigation of the SIRT family components associated with the pathogenesis of asthma is required. Also, we should investigate and affirm the viability and security of SIRT modulators in the treatment of asthma to get improved adequacy and stay away from antagonistic responses.

Select your language of interest to view the total content in your interested language

Latest issues

To read the issue click on a cover